Activity of the oral neuraminidase inhibitor A - 322278 against the oseltamivir - resistant H 274 Y ( A / H 1 N 1 ) influenza mutant in mice
نویسندگان
چکیده
count: 50 Text count: 1220 Inserts: 2 tables *Corresponding author: Guy Boivin, MD CHUQ-CHUL, room RC-709 2705 blvd Laurier, Sainte-Foy, Québec, Canada G1V 4G2 Tel : (418) 654-2705 Fax : (418) 654-2715 E-mail : [email protected] AC CE PT ED Copyright © 2008, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved. Antimicrob. Agents Chemother. doi:10.1128/AAC.01276-08 AAC Accepts, published online ahead of print on 17 November 2008 on N ovem er 8, 2017 by gest httpaac.asm .rg/ D ow nladed fom
منابع مشابه
Activity of the oral neuraminidase inhibitor A-322278 against the oseltamivir-resistant H274Y (A/H1N1) influenza virus mutant in mice.
The new oral neuraminidase (NA) inhibitor A-322278 was evaluated in mice infected with influenza A/H1N1 wild-type virus or the oseltamivir-resistant (H274Y mutant) virus. A-322278 decreased mortality rates and lung virus titers significantly more than oseltamivir in mice infected with the NA H274Y mutant when therapy was started 4 h before or even 48 h after infection.
متن کاملComparative activities of oseltamivir and A-322278 in immunocompetent and immunocompromised murine models of influenza virus infection.
We developed an immunocompromised murine model of influenza virus infection and demonstrated comparable efficacy of oral oseltamivir and A-322278 (both given at dosages of 10 mg/kg/day) in reducing viral replication, decreasing weight loss, and prolonging survival. Once the treatment was discontinued, severe combined immunodeficient (SCID) mice had progressive viral replication and clinical dec...
متن کاملشناسایی ویروسهای آنفلوانزای A/H3N2 مقاوم به اسلتامیویر با تست Real-time RT- PCR
Background: Currently, with increasing risk of influenza A virus epidemics, a lot of studies have been performed. Oseltamivir or Tamiflu (the neuraminidase (NA) inhibitor) is one of the effective drugs for preventing and treatment of these viruses. The H274Y mutation is from the most important drug resistant factors in influenza A viruses. The aim of this study was detection of Oseltamivir...
متن کاملSusceptibilities of antiviral-resistant influenza viruses to novel neuraminidase inhibitors.
The susceptibilities of five zanamivir-resistant and six oseltamivir-resistant influenza viruses were assessed against four neuraminidase (NA) inhibitors, including peramivir and A-315675, by a fluorometric NA activity inhibition assay. The enzyme activity of a majority of the variants was effectively inhibited by either A-315675 or both peramivir and A-315675 (50% inhibitory concentration, <10...
متن کاملComparison of the anti-influenza virus activity of RWJ-270201 with those of oseltamivir and zanamivir.
We have recently reported an influenza virus neuraminidase inhibitor, RWJ-270201 (BCX-1812), a novel cyclopentane derivative discovered through structure-based drug design. In this paper, we compare the potency of three compounds, RWJ-270201, oseltamivir, and zanamivir, against neuraminidase enzymes from various subtypes of influenza. RWJ-270201 effectively inhibited all tested influenza A and ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2008